Carisoprodol (trade names embody Soma, Somadril, Carisoma, Carisoprodol Watson, Listaflex, Somacid, Vanadom) is a muscle relaxant from carbamic acid esters pharmacological group. This medication is indicated together with rest and bodily remedy to relieve musculoskeletal ache, skeletal muscle spasms, stiffness, muscle accidents, pressure, sprain, acute back ache, discomfort associated with short-term, painful musculoskeletal circumstances, and for different medical functions. It can additionally be widely off-label used as leisure drug. Carisoprodol could additionally be prescribed alone for monotherapy or in combinations with other medication, similar to psycholeptics.
Clinical presentation </h2
Overdosage of Carisoprodol (Soma) tablets commonly produces CNS depression. Death, coma, respiratory melancholy, hypotension, seizures, delirium, hallucinations, dystonic reactions, nystagmus, blurred vision, mydriasis, euphoria, muscular incoordination, rigidity, and/or headache have been reported with Soma overdosage. Serotonin syndrome has been reported with carisoprodol intoxication. Many of the carisoprodol overdoses have occurred in the setting of a quantity of drug overdoses (including medicine of abuse, unlawful drugs, and alcohol). The effects of an overdose of this medication and other CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants) can be additive even when one of many medication has been taken in the recommended dosage. Fatal unintended and non-accidental overdoses of SOMA have been reported alone or in combination with CNS depressants.
Treatment of overdosage
Basic life help measures ought to be instituted as dictated by the medical presentation of the Soma overdose. Vomiting shouldn’t be induced due to the danger of CNS and respiratory despair, and subsequent aspiration. Circulatory assist must be administered with quantity infusion and vasopressor brokers if wanted. Seizures ought to be treated with intravenous benzodiazepines and the reoccurrence of seizures may be treated with phenobarbital. In cases of severe CNS depression, airway protective reflexes could also be compromised and tracheal intubation should be thought-about for airway safety and respiratory support.
For decontamination in cases of extreme toxicity, activated charcoal ought to be thought of in a hospital setting in patients with giant overdoses who current early and aren’t demonstrating CNS depression and may defend their airway.
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